5 edition of Ion Channel Regulation (Advances in Second Messenger and Phosphoprotein Research) found in the catalog.
April 15, 1999
by Academic Press
Written in English
|Contributions||David L. Armstrong (Editor), Sandra Rossie (Editor), Paul Greengard (Series Editor), Angus C. Nairn (Series Editor), Shirish Shenolikar (Series Editor)|
|The Physical Object|
|Number of Pages||318|
Buy (ebook) Ion Channel Regulation by Paul Greengard, David L. Armstrong, Shirish Shenolikar, Sandra Rossie, Angus C. Nairn, eBook format, from the Dymocks online bookstore. Cell-matrix adhesion determines the choice between different cell fates and is accompanied by substantial changes in ion transport. The greatest evidence is the bidirectional interplay occurring between integrin receptors and K+ channels. These proteins can form signaling hubs that regulate cell proliferation, differentiation, and migration in normal and neoplastic by: 5.
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. A striking number of drugs targeting ion channels have reached blockbuster status, generating $ billion revenues. In spite of the historical success of ion channels as therapeutic targets and the considerable investment in this target class by the industry, not a single novel, small molecule ion channel drug has been approved by the FDA in the past 10 years.
The regulation of ion channels by growth factors and receptor PTKs has been reviewed, to some extent, previously (3,4,6,7). The pur-pose of the present work is to summarize evi-dence for the regulation of ion channels by integrins and integrin-linked tyrosine kinases. We review both direct and indirect evidence for this regulation. Ion Channels and Receptors (Morgan Sheng, lectures 1 and 2) Importance of ion channels in nervous system and neural signaling – ion channels are the molecular basis of membrane excitability (synaptic transmission, action potentials, sensory transduction etc)File Size: 1MB.
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Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Enter your mobile number or email address below and we'll send you a link to download the free Kindle App.
Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device required/5(6). Written specifically to introduce non-electrophysiologists to ion channels as proteins and to introduce electrophysiologists to signal transduction pathways, Ion Channel Regulation represents a unique.
Sterol Regulation of Ion Channels (ISSN Book 80) - Kindle edition by Levitan, Irena. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Sterol Regulation of Ion Channels (ISSN Book 80).
Ion channels have been transformed during the past years into signaling proteins that regulate every aspect of cell physiology. This book provides an understanding of the molecular mechanisms that control ion channel activity.
It also explains how channels are used to stimulate growth and changes to activity of the nucleus and genome. Sterol Regulation of Ion Channels, Vol the latest in the Current Topics in Membranes series provides outstanding content to the scientific community on relevant topics that relate to.
DOI link for Handbook of Ion Channels. Handbook of Ion Channels book. Edited By Jie Zheng, Matthew C. Trudeau.
Edition 1st Edition. First Published eBook Published 25 February PART IV ION CHANNEL REGULATION. chapter 34 | 14 pages Mechanism of G-Protein Regulation of K+ Channels.
With Rahul Mahajan, Diomedes E. Logothetis Cited by: Clearly, the subject of ion channel regulation is multi-faceted, with a large number of very talented scientists working in the field.
The NATO Symposium represented an attempt to bring together these individuals and synthesize and evaluate new ideas and experimental findings. The volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.
This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. In our opinion the book presents not only the.
Book February regulation of ion homeostasis, organellar trafficking, and other key cellular and organismal activities. Unlike most other ion channels, TRP channels are often polymodal.
The manual includes background on the structure, function, and regulation of different voltage- and ligand-gated ion channels. Therefore, it is a useful resource for all cell biologists and neuroscientists seeking to further understand the complex roles of ion channels in physiology and disease. Vital homeostatic mechanisms monitor O 2 supply and adjust respiratory and circulatory function to meet demand.
The pulmonary arteries and carotid bodies are key systems in this respect. Hypoxic pulmonary vasoconstriction (HPV) aids ventilation−perfusion matching in the lung by diverting blood flow from areas with an O 2 deficit to those rich in O 2, while a fall in arterial pO 2 increases Cited by: Understanding cholesterol regulation of ion channels and receptors is essential for facilitating the development of new therapeutic strategies to alleviate the impact of pathological cholesterol conditions.
With this book as their guide, readers have access to. A leading U.S. general entertainment network, ION Television’s Positively Entertaining lineup features major cable & broadcast shows, original series and special event programming. The chapters on Ion Channel Families provide excellent summaries of the structure, function, and physiological role of the myriad families.
This section will be exceptionally useful. However, it suffers from perhaps the biggest flaw in the by: 1. Xu TL, Duan B (). Calcium-permeable acid-sensing ion channel in nociceptive plasticity: a new target for pain control.
Prog Neurobiol – Xu TL, Xiong ZG (). Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators. Curr Med Chem– Comprehensive and highly practical, Ion Channels: Methods and Protocols offer both novice and experienced researchers a versatile collection of proven techniques for illuminating the structure, function, and regulation of ion channel proteins and finding suitable drug targets when they cause disease.
The responsiveness of ion channels to membrane potential and neurotransmitters is also regulated on the time scale of seconds to minutes. Protein phosphorylation is now implicated as an important component of this second-order regulation of ion channel by: 3.
channel; rather, many, and perhaps all, ion channels are subject to modulation by phosphorylation. Similarly, a number of different protein kinase signaling pathways can participate in the regulation of ion channel properties, and it is not unusual to find that a particular channel.
Some ion channels are selective for charge but not necessarily for size, and thus are called a nonspecific channel. These nonspecific channels allow cations—particularly Na +, K +, and Ca 2+ —to cross the membrane, but exclude anions.
Ion channels. Ligand-gated ion channels (LGICs) mediate passive ion flux driven by the electrochemical gradient for the permeant ions.
LGICs are gated by the binding of a specific ligand to an orthosteric site(s) that triggers a conformational change that results in the conducting state, or by binding of endogenous, or exogenous, modulators to allosteric sites.
Beschreibung. Ion channels have been transformed during the past years into signaling proteins that regulate every aspect of cell physiology. This book provides an understanding of the molecular mechanisms that control ion channel activity.K channel diversity / O.
Pongs --Regulation of voltage-activated K channels / A.M. Brown --Gating mechanisms of Shaker potassium channels / R.
Aldrich --Vaccinia virus: a novel expression system for receptors and ion channels / A. Karschin --Delayed rectification in the heart: regulation and physiology / W.M.
Kwok [and others] --Receptor.Ion Channels: Communication across Membranes The structural biology of voltage-gated calcium channel function and regulation F.
Van Petegem and D.L. Minor, Jr1 Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, Cardiovascular Research Institute, California Institute of Quantitative.